Sinoatrial node cell development

Across TCGA patient cohorts, RNA activity of the Sinoatrial node cell development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD248, COL5A1, and FKBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sinoatrial node cell development activity versus CD248 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD248 →	+0.473	+0.446	<.001	<.001	3	8
PDAC	COL5A1 →	+0.750	+0.067	<.001	<.001	3	7
HNSC	FKBP7 →	+0.427	+0.112	.001	<.001	3	6
PDAC	GSN →	+0.787	+0.065	<.001	<.001	3	6
UCEC	MMP2 →	+0.787	+0.475	<.001	.002	3	6
OV	THBS2 →	+1.182	+0.451	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060931 vs CD248 — UCEC

Explore this scatter interactively →