Sinoatrial node cell development

Across TCGA pan-cancer cohorts, RNA activity of the Sinoatrial node cell development pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in stomach adenocarcinoma (STAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as STAD and KIRC, show the opposite pattern, with lower activity in tumor tissue.

STAD, KIRC, and THCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
STAD	Female	All	−0.232	<.001	10	view →
KIRC	Male	II,III,IV	−0.174	<.001	10	view →
THCA	Female	II,III,IV	+0.197	<.001	7	view →
LUAD	Female	All	−0.088	<.001	7	view →
BRCA	All	III,IV	−0.070	<.001	6	view →
CHOL	All	All	−0.309	<.001	3	view →
LIHC	Female	All	−0.160	.001	3	view →
KIRP	Female	All	−0.121	.001	3	view →
HNSC	All	IV	+0.064	.007	3	view →
COAD	Female	II,III,IV	+0.074	.021	2	view →
PRAD	All	All	−0.058	<.001	2	view →
ESCA	All	All	−0.123	.012	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0060931–STAD

Open the STAD breakdown →