Sinoatrial node cell development

Across TCGA patient cohorts, RNA activity of the Sinoatrial node cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX3, BRSK1, and HIGD1B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sinoatrial node cell development activity versus TBX3 in BRCA (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBX3 →	+1.356	+1.043	<.001	<.001	3	8
UCEC	BRSK1 →	+0.870	+0.209	<.001	<.001	3	5
CCRCC	HIGD1B →	+1.164	+0.242	<.001	<.001	3	4
BRCA	PALM →	+1.144	+0.699	<.001	.002	3	4
BRCA	NFATC4 →	+0.917	+0.689	.001	.003	3	4
BRCA	RAP1GDS1 →	+0.756	+0.946	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060931 vs TBX3 — BRCA

Explore this scatter interactively →