Sinoatrial node cell development

Across TCGA cell cohorts, RNA activity of the Sinoatrial node cell development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IST1, ATXN1L, and E2F8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IST1 grouped by Sinoatrial node cell development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IST1 →	+0.530	+1.001	<.001	.001	3	4
LARGE_INTESTINE	ATXN1L →	+0.551	+1.048	.007	.008	3	4
OVARY	E2F8 →	+0.974	+1.184	<.001	<.001	3	4
SKIN	IFI44L →	+1.567	+1.043	.002	.003	3	4
BREAST	DENND2D →	+2.067	+0.929	.001	.002	3	4
STOMACH	GABPA →	-0.601	-1.350	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IST1 by Sinoatrial node cell development activity — LARGE_INTESTINE

Explore this box plot interactively →