Cardiac pacemaker cell development

Across TCGA patient cohorts, RNA activity of the Cardiac pacemaker cell development pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX3, BRAF, and ARID1B, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac pacemaker cell development activity versus TBX3 in TGCT (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	TBX3 →	+1.909	+0.095	<.001	<.001	3	28
DLBC	BRAF →	+0.824	+0.064	<.001	<.001	3	24
DLBC	ARID1B →	+0.898	+0.055	<.001	<.001	2	25
SARC	BMPR1A →	+0.709	+0.068	<.001	<.001	3	23
THYM	SMAD5 →	+1.242	+0.075	<.001	<.001	3	23
SKCM	TTC21B →	+0.592	+0.032	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060926 vs TBX3 — TGCT

Explore this scatter interactively →