Cardiac pacemaker cell development

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac pacemaker cell development pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Cardiac pacemaker cell development pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and UCS, show the opposite pattern, with higher activity associated with better survival.

BLCA, LGG, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.676	0.542	.004	58	view →
LGG	OS	Median	All	0.344	0.531	<.001	50	view →
UCS	OS	Median	III,IV	0.511	0.206	.015	34	view →
BRCA	OS	Quartile	All	0.455	0.696	.001	29	view →
CESC	OS	Quartile	II,III,IV	0.775	0.348	.018	22	view →
ACC	DFS	Median	III,IV	0.826	0.290	.001	21	view →
HNSC	OS	Tertile	All	0.571	0.752	.009	18	view →
MESO	DFS	Median	III,IV	0.199	0.581	.020	15	view →
KIRC	OS	Median	All	0.684	0.583	.013	13	view →
PRAD	DFS	Median	All	0.918	0.855	.021	12	view →
PAAD	DFS	Quartile	All	0.528	0.219	.004	12	view →
LUAD	DFS	Median	III,IV	0.804	0.550	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0060926–BLCA (DFS)

Open the BLCA breakdown →