Cardiac pacemaker cell development

Across TCGA patient cohorts, RNA activity of the Cardiac pacemaker cell development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, NAGK, and ARHGDIB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac pacemaker cell development activity versus RCSD1_S351 in OV (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1_S351 →	-0.580	-0.105	.004	<.001	3	5
OV	NAGK →	-0.336	-0.084	<.001	<.001	3	5
OV	ARHGDIB →	-0.631	-0.101	<.001	<.001	3	5
LSCC	GPSM3 →	-0.319	-0.075	.001	<.001	3	5
UCEC	PRPF40A_T346 →	-0.390	-0.159	<.001	<.001	3	5
UCEC	CASK →	+0.348	+0.142	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060926 vs RCSD1_S351 — OV

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