Cardiac pacemaker cell development

Across TCGA patient cohorts, RNA activity of the Cardiac pacemaker cell development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBX3_S375, TBX3_S707, and TBX3_S456, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac pacemaker cell development activity versus TBX3_S375 in BRCA (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBX3_S375 →	+1.787	+1.268	<.001	<.001	3	5
BRCA	TBX3_S707 →	+1.030	+0.821	<.001	<.001	3	5
BRCA	TBX3_S456 →	+1.120	+0.692	<.001	<.001	3	5
BRCA	IRF2BP1_S384 →	+0.520	+0.682	.001	.001	2	5
BRCA	SRRM2_S1876 →	+0.736	+0.734	.003	.001	2	5
OV	BCL9L_S21 →	+0.546	+0.263	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060926 vs TBX3_S375 — BRCA

Explore this scatter interactively →