Cardiac pacemaker cell development

Across TCGA cell cohorts, RNA activity of the Cardiac pacemaker cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODXL2, TAS2R31, and XPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PODXL2 grouped by Cardiac pacemaker cell development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PODXL2 →	-1.581	-1.119	.003	<.001	3	4
BLOOD_Myeloma	TAS2R31 →	+0.224	+1.742	.003	.002	3	3
LUNG_NSCLC_LUSC	XPA →	+0.795	+1.058	.004	.001	3	3
KIDNEY	WASL →	+1.008	+1.336	.004	.007	3	3
UPPER_AERODIGESTIVE_TRACT	SPIRE1 →	+1.225	+1.397	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ADCY1 →	-1.033	-1.278	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PODXL2 by Cardiac pacemaker cell development activity — LUNG_SCLC

Explore this box plot interactively →