Cardiac pacemaker cell development

Across TCGA cell cohorts, RNA activity of the Cardiac pacemaker cell development pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM48, PIP4P1, and ATP13A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM48 grouped by Cardiac pacemaker cell development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TRIM48 →	-0.224	-0.193	.003	<.001	3	4
LIVER	PIP4P1 →	+0.164	+0.196	.006	.005	3	4
LIVER	ATP13A4 →	+0.200	+0.168	.002	.009	3	3
LIVER	MED22 →	-0.132	-0.199	<.001	<.001	3	3
LUNG_SCLC	ST6GALNAC5 →	+0.189	+0.136	.004	.003	3	3
CNS	PACS1 →	+0.550	+0.309	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM48 by Cardiac pacemaker cell development activity — LIVER

Explore this box plot interactively →