Cardiac pacemaker cell differentiation

Across TCGA cell cohorts, RNA activity of the Cardiac pacemaker cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COLEC11, SLC38A7, and MMAA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COLEC11 grouped by Cardiac pacemaker cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	COLEC11 →	+0.227	+0.177	.002	.005	3	3
BREAST	SLC38A7 →	+0.307	+0.147	<.001	.002	3	3
BREAST	MMAA →	-0.193	-0.134	.001	.002	3	3
STOMACH	NXPH1 →	+0.291	+0.133	.005	<.001	3	3
BLOOD_Myeloma	CD46 →	-0.194	-1.311	.002	<.001	3	3
LARGE_INTESTINE	SIN3A →	-0.352	-0.145	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COLEC11 by Cardiac pacemaker cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →