Cardiac cell fate commitment

Across TCGA cell cohorts, RNA activity of the Cardiac cell fate commitment pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKX2-5, SOX17, and DKK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NKX2-5 grouped by Cardiac cell fate commitment-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-5 →	-0.253	-1.097	<.001	<.001	3	6
OVARY	SOX17 →	-0.253	-1.164	<.001	<.001	3	6
KIDNEY	DKK1 →	-0.244	-1.523	.001	.001	2	6
LIVER	ATOH7 →	-0.304	-1.110	<.001	.008	3	5
CNS	TAS2R50 →	-0.172	-1.035	.001	<.001	3	5
BLOOD_Myeloma	POU4F3 →	-0.371	-1.557	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NKX2-5 by Cardiac cell fate commitment activity — BLOOD_Leukemia

Explore this box plot interactively →