Cardiac cell fate commitment

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac cell fate commitment pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Cardiac cell fate commitment pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and ESCA, show the opposite pattern, with higher activity associated with better survival.

UVM, ESCA, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	II,III,IV	1.000	0.360	<.001	77	view →
ESCA	OS	Median	All	0.800	0.594	.001	48	view →
LUAD	OS	Quartile	All	0.584	0.728	.003	38	view →
SKCM	OS	Median	All	0.376	0.309	.004	26	view →
MESO	OS	Tertile	III,IV	0.271	0.710	.006	18	view →
THYM	DFS	Tertile	II,III,IV	0.927	0.437	.010	12	view →
BRCA	OS	Tertile	All	0.482	0.595	.007	11	view →
COAD	DFS	Median	III,IV	0.544	0.740	.020	11	view →
KIRC	DFS	Median	II,III,IV	0.738	0.856	.016	7	view →
UCS	OS	Tertile	II,III,IV	0.646	0.299	.020	6	view →
ACC	OS	Median	IV	0.344	0.724	.038	6	view →
CHOL	OS	Median	IV	0.136	0.829	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0060911–UVM (OS)

Open the UVM breakdown →