Hair follicle placode formation

Across TCGA cell cohorts, RNA activity of the Hair follicle placode formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLYCD, PLXNB1, and SDCBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MLYCD grouped by Hair follicle placode formation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MLYCD →	+0.871	+1.339	.007	.008	2	6
CNS	PLXNB1 →	+1.194	+1.174	<.001	<.001	3	5
LUNG_NSCLC_LUAD	SDCBP →	-0.878	-1.198	.009	<.001	3	5
LUNG_SCLC	PDIA4 →	+0.982	+1.223	.003	<.001	3	4
BLOOD_Lymphoma	PRKAR1A →	+1.163	+1.928	<.001	<.001	3	4
CNS	FGFRL1 →	+0.975	+0.965	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MLYCD by Hair follicle placode formation activity — BLOOD_Myeloma

Explore this box plot interactively →