Regulation of response to cytokine stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of response to cytokine stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP3, TRIM5, and ITPRIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to cytokine stimulus activity versus LRP3 in LUNG_NSCLC_LUAD (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LRP3 →	+1.362	+0.112	.003	.001	3	4
SOFT_TISSUE	TRIM5 →	-0.924	-0.203	.008	<.001	3	4
SOFT_TISSUE	ITPRIP →	-1.916	-0.192	<.001	.002	3	4
BLOOD_Lymphoma	ATP8A1 →	+1.075	+0.207	.006	<.001	3	4
LARGE_INTESTINE	BAMBI →	+3.246	+0.152	.001	<.001	3	4
BLOOD_Leukemia	SH3BGRL2 →	-1.244	-0.146	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060759 vs LRP3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →