Chorionic trophoblast cell differentiation

Across TCGA patient cohorts, RNA activity of the Chorionic trophoblast cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, RRM2_S20, and SMC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chorionic trophoblast cell differentiation activity versus RRM2 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RRM2 →	+0.593	+0.114	<.001	<.001	3	7
LSCC	RRM2_S20 →	+0.709	+0.068	<.001	<.001	3	7
BRCA	SMC2 →	+0.668	+0.052	<.001	<.001	3	7
OV	SMC4 →	+0.450	+0.064	<.001	<.001	3	7
BRCA	TOP2A →	+0.984	+0.054	<.001	<.001	3	7
COAD	CHAF1B →	+0.681	+0.089	.004	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060718 vs RRM2 — LSCC

Explore this scatter interactively →