Trophoblast giant cell differentiation

Across TCGA patient cohorts, RNA activity of the Trophoblast giant cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTX3, SMC2, and RRM2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trophoblast giant cell differentiation activity versus PTX3 in GBM (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTX3 →	+0.765	+0.064	.002	<.001	3	9
LUAD	SMC2 →	+0.559	+0.089	<.001	<.001	3	8
LUAD	RRM2 →	+0.777	+0.101	<.001	<.001	3	8
LUAD	RRM2_S20 →	+1.340	+0.086	<.001	<.001	3	8
LUAD	SMC4 →	+0.550	+0.089	<.001	<.001	3	8
LUAD	H1-10_S31 →	+0.913	+0.087	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060707 vs PTX3 — GBM

Explore this scatter interactively →