Trophoblast giant cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Trophoblast giant cell differentiation pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Trophoblast giant cell differentiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and UCEC, show the opposite pattern, with higher activity associated with better survival.

KIRP, KIRC, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.813	0.937	<.001	150	view →
KIRC	DFS	Median	All	0.507	0.716	<.001	116	view →
LUAD	OS	Median	All	0.587	0.762	<.001	80	view →
LIHC	DFS	Quartile	All	0.408	0.570	.002	76	view →
MESO	OS	Median	All	0.263	0.500	<.001	70	view →
LGG	DFS	Median	All	0.624	0.819	<.001	54	view →
ACC	OS	Tertile	II,III,IV	0.601	0.907	<.001	46	view →
UCS	OS	Tertile	II,III,IV	0.840	0.414	.004	22	view →
HNSC	OS	Median	III,IV	0.551	0.785	.002	20	view →
BRCA	OS	Median	II,III,IV	0.886	0.935	.003	17	view →
UCEC	OS	Median	IV	0.848	0.610	.015	16	view →
GBM	DFS	Median	All	0.366	0.204	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0060707–KIRP (OS)

Open the KIRP breakdown →