Regulation of phospholipid catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of phospholipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCKAP1L, WDFY4, and ITGAX, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid catabolic process activity versus NCKAP1L in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCKAP1L →	+0.386	+0.062	<.001	.001	3	7
GBM	WDFY4 →	+0.314	+0.071	<.001	<.001	3	6
GBM	ITGAX →	+0.504	+0.089	.004	.002	3	6
GBM	APBB1IP →	+0.634	+0.119	<.001	<.001	3	6
GBM	SAMSN1_S23 →	+0.785	+0.098	<.001	<.001	3	5
UCEC	DOK2 →	+0.502	+0.096	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060696 vs NCKAP1L — GBM

Explore this scatter interactively →