Regulation of phospholipid catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDT1, SMIM10L1, and ABRAXAS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDT1 grouped by Regulation of phospholipid catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CDT1 →	+0.739	+0.942	.003	<.001	3	5
KIDNEY	SMIM10L1 →	-0.572	-1.335	.002	.003	3	4
URINARY_TRACT	ABRAXAS2 →	+0.294	+1.610	.004	.002	3	4
BREAST	NCAPH →	+0.654	+0.711	.002	.001	3	3
BREAST	CENPS →	+0.644	+1.043	.001	<.001	3	3
BREAST	HASPIN →	+0.612	+0.818	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDT1 by Regulation of phospholipid catabolic process activity — BREAST

Explore this box plot interactively →