Regulation of chromosome condensation

Across TCGA cell cohorts, RNA activity of the Regulation of chromosome condensation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALY, ABHD14A, and RAB35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RALY grouped by Regulation of chromosome condensation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RALY →	+0.300	+0.178	.003	<.001	3	4
BREAST	ABHD14A →	-0.155	-0.153	.003	<.001	3	4
LUNG_SCLC	RAB35 →	+0.432	+0.167	.004	<.001	3	4
LIVER	S100A11 →	+0.191	+0.162	.009	.005	3	4
LUNG_SCLC	MRPS6 →	+0.245	+0.193	.001	<.001	3	4
BLOOD_Leukemia	UQCR11 →	-0.242	-0.137	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RALY by Regulation of chromosome condensation activity — BREAST

Explore this box plot interactively →