Adipose tissue development

Across TCGA cell cohorts, RNA activity of the Adipose tissue development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYTL1, DDX10, and GALK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYTL1 grouped by Adipose tissue development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SYTL1 →	-1.038	-0.325	.007	.002	3	3
UPPER_AERODIGESTIVE_TRACT	DDX10 →	+0.970	+0.244	.003	.008	3	3
STOMACH	GALK1 →	-1.603	-0.799	.008	.004	3	3
KIDNEY	ODC1 →	+1.061	+0.909	<.001	.005	3	3
SKIN	DYNLT1 →	-0.427	-0.726	.006	.006	2	4
CNS	DDIT3 →	-0.871	-0.576	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYTL1 by Adipose tissue development activity — OESOPHAGUS

Explore this box plot interactively →