Adipose tissue development

Across TCGA cell cohorts, RNA activity of the Adipose tissue development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCAR2, GTF2F1, and PPP1CC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adipose tissue development activity versus CCAR2 in BLOOD_Myeloma (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCAR2 →	-1.099	-0.424	.001	.001	3	5
PANCREAS	GTF2F1 →	-0.820	-0.378	<.001	<.001	3	4
OVARY	PPP1CC →	-0.628	-0.151	.004	.003	3	4
OVARY	CFI →	+2.429	+0.161	.001	.001	3	4
PANCREAS	LIPH →	+2.108	+0.301	.008	.003	2	5
PANCREAS	SNAPC4 →	-0.987	-0.400	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060612 vs CCAR2 — BLOOD_Myeloma

Explore this scatter interactively →