Dichotomous subdivision of an epithelial terminal unit

Across TCGA patient cohorts, RNA activity of the Dichotomous subdivision of an epithelial terminal unit pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI1, RBMXP5, and CELSR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dichotomous subdivision of an epithelial terminal unit activity versus GNAI1 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GNAI1 →	+0.325	+0.307	.005	.001	3	3
LSCC	RBMXP5 →	+0.887	+0.463	<.001	<.001	3	3
BRCA	CELSR1 →	+0.882	+0.450	.003	.001	3	3
HNSC	HMGB1P16 →	+0.429	+0.252	.005	.005	3	3
BRCA	CA12 →	+1.206	+0.298	.005	.007	3	3
COAD	TEN1-CDK3 →	+0.121	+0.524	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060600 vs GNAI1 — LSCC

Explore this scatter interactively →