Acrosomal vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Acrosomal vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRY2, MLYCD, and DIRAS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acrosomal vesicle exocytosis activity versus CRY2 in BRCA (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRY2 →	+0.496	+0.673	.009	.003	3	5
GBM	MLYCD →	+0.487	+0.935	<.001	<.001	3	5
GBM	DIRAS2 →	+1.193	+0.804	<.001	<.001	3	5
GBM	TOX3 →	+1.264	+0.942	<.001	<.001	3	4
GBM	PDE1A →	+1.040	+0.883	<.001	<.001	3	4
BRCA	C1orf21 →	+1.016	+0.792	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060478 vs CRY2 — BRCA

Explore this scatter interactively →