Acrosomal vesicle exocytosis

Across TCGA pan-cancer cohorts, RNA activity of the Acrosomal vesicle exocytosis pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Acrosomal vesicle exocytosis pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and LGG, show the opposite pattern, with higher activity associated with better survival.

LIHC, ACC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.589	0.776	<.001	61	view →
ACC	DFS	Median	All	0.272	0.642	<.001	60	view →
BRCA	OS	Median	All	0.640	0.487	<.001	48	view →
UCS	OS	Median	II,III,IV	0.193	0.616	.002	44	view →
LGG	OS	Quartile	All	0.527	0.332	.001	26	view →
BLCA	DFS	Tertile	III,IV	0.472	0.653	.007	23	view →
GBM	OS	Median	All	0.256	0.545	<.001	18	view →
PRAD	DFS	Tertile	All	0.482	0.852	<.001	18	view →
HNSC	OS	Quartile	II,III,IV	0.803	0.669	.003	16	view →
PCPG	OS	Median	All	0.627	1.000	.004	15	view →
KIRP	OS	Median	II,III,IV	0.706	0.256	.013	15	view →
KICH	OS	Median	All	0.756	0.949	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0060478–LIHC (OS)

Open the LIHC breakdown →