Acrosomal vesicle exocytosis

Across TCGA cell cohorts, RNA activity of the Acrosomal vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRX5, ZFYVE28, and TRAIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRX5 grouped by Acrosomal vesicle exocytosis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IRX5 →	+0.809	+0.887	.004	.001	3	5
BLOOD_Leukemia	ZFYVE28 →	+1.852	+1.488	.002	.002	3	5
BLOOD_Myeloma	TRAIP →	+1.241	+2.047	<.001	<.001	3	5
PANCREAS	CISD2 →	-0.651	-1.738	.003	<.001	3	4
STOMACH	CYB561D2 →	+1.396	+1.726	.007	.001	3	4
BLOOD_Lymphoma	ARIH2 →	+0.959	+1.857	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRX5 by Acrosomal vesicle exocytosis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →