Epithelial tube branching involved in lung morphogenesis

Across TCGA cell cohorts, RNA activity of the Epithelial tube branching involved in lung morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACP7, CTSZ, and RNASE1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial tube branching involved in lung morphogenesis activity versus ACP7 in PANCREAS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ACP7 →	+2.389	+0.281	.002	.002	3	3
LUNG_NSCLC_LUAD	CTSZ →	+1.368	+0.948	.002	.003	3	2
PANCREAS	RNASE1 →	+5.380	+0.259	<.001	.008	3	2
PANCREAS	SPART →	+3.262	+0.259	.003	.008	3	2
PANCREAS	TMEM229B →	+1.817	+0.269	.007	.005	3	2
LUNG_NSCLC_LUAD	ASCC2 →	-0.373	-0.620	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060441 vs ACP7 — PANCREAS

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