Epithelial tube branching involved in lung morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Epithelial tube branching involved in lung morphogenesis pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUSC and HNSC, show the opposite pattern, with lower activity in tumor tissue.

THCA, COAD, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Male	All	+0.050	<.001	10	view →
COAD	Female	All	+0.046	<.001	10	view →
LUSC	Male	II,III,IV	−0.046	<.001	7	view →
HNSC	Female	II,III,IV	−0.071	<.001	6	view →
KICH	Male	All	−0.057	<.001	6	view →
BRCA	Female	All	−0.056	<.001	6	view →
LUAD	All	III,IV	−0.041	.003	6	view →
LIHC	All	All	+0.030	<.001	5	view →
KIRC	Male	III,IV	−0.028	.011	4	view →
PAAD	All	All	+0.077	.011	2	view →
STAD	Female	All	−0.072	.026	2	view →
CHOL	All	All	+0.062	.007	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0060441–THCA

Open the THCA breakdown →