Ventricular septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Ventricular septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASXL1, CTPS1, and CHD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular septum morphogenesis activity versus ASXL1 in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASXL1 →	+0.457	+0.446	<.001	.003	3	6
LUAD	CTPS1 →	+0.485	+0.625	<.001	<.001	3	5
LSCC	CHD4 →	+0.330	+0.381	<.001	.002	3	4
GBM	ZNF133 →	+0.441	+0.572	<.001	.001	3	4
LSCC	TBC1D31 →	+0.569	+0.486	<.001	.001	3	4
LSCC	NPIPP1 →	+0.478	+0.450	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060412 vs ASXL1 — LSCC

Explore this scatter interactively →