Ventricular septum morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Ventricular septum morphogenesis pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 43 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Ventricular septum morphogenesis pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and BRCA, show the opposite pattern, with higher activity associated with better survival.

ACC, MESO, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.250	0.747	<.001	103	view →
MESO	OS	Median	II,III,IV	0.277	0.481	<.001	81	view →
SCLC	DFS	Median	III,IV	0.741	0.301	.001	35	view →
KIRP	OS	Quartile	II,III,IV	0.379	0.772	.007	32	view →
BRCA	OS	Median	All	0.977	0.947	.005	30	view →
KICH	DFS	Tertile	III,IV	0.378	0.904	.014	21	view →
HNSC	DFS	Quartile	IV	0.725	0.534	.006	21	view →
ESCA	OS	Median	III,IV	0.578	0.317	.007	20	view →
THCA	OS	Tertile	III,IV	0.939	1.000	.001	19	view →
UCS	DFS	Quartile	II,III,IV	0.558	0.101	.016	18	view →
COAD	DFS	Tertile	All	0.593	0.752	.008	14	view →
STAD	DFS	Tertile	All	0.388	0.642	.030	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0060412–ACC (OS)

Open the ACC breakdown →