Growth hormone receptor signaling pathway via JAK-STAT

Across TCGA cell cohorts, RNA activity of the Growth hormone receptor signaling pathway via JAK-STAT pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT5B, STAT3, and KSR1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth hormone receptor signaling pathway via JAK-STAT activity versus STAT5B in BLOOD_Myeloma (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	STAT5B →	+1.316	+0.142	<.001	.001	3	17
BLOOD_Lymphoma	STAT3 →	+1.877	+0.192	<.001	<.001	3	11
BLOOD_Lymphoma	KSR1 →	+2.569	+0.146	<.001	<.001	3	10
LUNG_NSCLC_LUSC	PTPN1 →	+1.162	+0.158	.001	.001	3	9
OVARY	JAK1 →	+1.301	+0.158	<.001	<.001	3	9
BLOOD_Leukemia	LYN →	+2.005	+0.179	<.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060397 vs STAT5B — BLOOD_Myeloma

Explore this scatter interactively →