Negative regulation of SMAD protein signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of SMAD protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, PRKG1, and TRIM33_S862, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of SMAD protein signal transduction activity versus KANK2 in COAD (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KANK2 →	+0.446	+0.041	.001	<.001	3	10
OV	PRKG1 →	+0.888	+0.060	<.001	<.001	3	9
GBM	TRIM33_S862 →	-0.536	-0.077	.002	<.001	3	8
OV	TAGLN →	+1.354	+0.066	<.001	<.001	3	8
OV	TPM1 →	+0.809	+0.051	<.001	<.001	3	8
COAD	RRM2 →	-0.472	-0.040	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060392 vs KANK2 — COAD

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