Negative regulation of SMAD protein signal transduction

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of SMAD protein signal transduction pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Negative regulation of SMAD protein signal transduction pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and ESCA, show the opposite pattern, with higher activity associated with better survival.

KIRC, ESCA, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.640	0.311	<.001	89	view →
ESCA	OS	Median	II,III,IV	0.798	0.545	<.001	77	view →
LGG	DFS	Median	All	0.478	0.315	<.001	54	view →
KIRP	DFS	Tertile	III,IV	0.781	0.388	.003	50	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.612	.015	43	view →
MESO	OS	Median	II,III,IV	0.197	0.367	.016	39	view →
ACC	DFS	Median	All	0.768	0.363	.001	28	view →
CESC	DFS	Tertile	All	0.659	0.796	.019	20	view →
UVM	OS	Median	All	1.000	0.754	.005	16	view →
STAD	DFS	Quartile	All	0.331	0.528	.017	14	view →
BLCA	OS	Median	IV	0.181	0.344	.017	10	view →
THCA	OS	Quartile	III,IV	0.663	1.000	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0060392–KIRC (DFS)

Open the KIRC breakdown →