Negative regulation of SMAD protein signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of SMAD protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC25A, DCN, and C1QTNF7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of SMAD protein signal transduction activity versus CDC25A in LSCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDC25A →	-0.825	-0.572	<.001	<.001	3	6
OV	DCN →	+1.492	+0.211	<.001	<.001	3	5
OV	C1QTNF7 →	+0.794	+0.156	.003	.005	2	6
OV	LMOD1 →	+1.055	+0.198	<.001	<.001	3	5
OV	LHFPL6 →	+0.896	+0.171	.002	.003	3	5
LSCC	ZEB1 →	+0.406	+0.519	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060392 vs CDC25A — LSCC

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