Negative regulation of SMAD protein signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of SMAD protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC3, F2R, and TBC1D3I, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCC3 grouped by Negative regulation of SMAD protein signal transduction-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ABCC3 →	+1.704	+1.174	.003	.006	3	4
BLOOD_Leukemia	F2R →	+1.796	+0.924	.005	<.001	3	3
BLOOD_Leukemia	TBC1D3I →	-0.108	-1.217	.005	<.001	3	3
BLOOD_Leukemia	ALS2 →	+1.064	+0.932	.007	.005	3	3
OVARY	ARMC5 →	+0.412	+1.143	<.001	<.001	3	3
OVARY	STEAP1 →	-1.885	-0.884	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCC3 by Negative regulation of SMAD protein signal transduction activity — KIDNEY

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