Negative regulation of SMAD protein signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of SMAD protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASF1B, HIRA, and SEM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of SMAD protein signal transduction activity versus ASF1B in STOMACH (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ASF1B →	+1.740	+1.611	.002	.003	3	6
PANCREAS	HIRA →	+0.807	+1.224	.004	.005	3	5
LUNG_NSCLC_LUAD	SEM1 →	+0.583	+0.834	.003	.009	3	5
LUNG_SCLC	RBBP4 →	+0.929	+0.312	.001	.002	3	5
URINARY_TRACT	RPS19BP1 →	+0.728	+1.229	.003	.003	3	5
BREAST	PTP4A2 →	+0.762	+0.908	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060392 vs ASF1B — STOMACH

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