Positive regulation of Fc receptor mediated stimulatory signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2N2, HNRNPUL1, and POU2F1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAMK2N2 grouped by Positive regulation of Fc receptor mediated stimulatory signaling pathway-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CAMK2N2 →	-0.612	-1.017	.003	.002	3	5
PANCREAS	HNRNPUL1 →	-0.668	-0.863	.001	.005	3	4
SOFT_TISSUE	POU2F1 →	-0.744	-1.824	.006	<.001	3	4
URINARY_TRACT	SPAG8 →	-0.532	-1.995	.002	<.001	3	4
URINARY_TRACT	TRIM72 →	-0.032	-1.809	<.001	.001	3	4
KIDNEY	POLDIP3 →	-0.718	-1.142	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAMK2N2 by Positive regulation of Fc receptor mediated stimulatory signaling pathway activity — KIDNEY

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