Positive regulation of Fc receptor mediated stimulatory signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPN, PMM1, and AKAP10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASPN grouped by Positive regulation of Fc receptor mediated stimulatory signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASPN →	+0.163	+1.738	.002	<.001	3	3
BLOOD_Leukemia	PMM1 →	-0.230	-1.507	.001	<.001	3	3
BLOOD_Leukemia	AKAP10 →	-0.234	-1.113	.003	.004	3	3
BLOOD_Leukemia	NLRP3 →	+0.300	+1.405	.007	.002	3	3
BREAST	DMTF1 →	+0.227	+1.112	.002	<.001	3	3
KIDNEY	PTDSS1 →	-0.330	-2.048	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASPN by Positive regulation of Fc receptor mediated stimulatory signaling pathway activity — OVARY

Explore this box plot interactively →