Negative regulation of cell adhesion molecule production

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell adhesion molecule production pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1S, LGALS1, and FKBP10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell adhesion molecule production activity versus C1S in BRCA (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C1S →	+0.545	+0.067	<.001	<.001	3	7
UCEC	LGALS1 →	+0.587	+0.142	<.001	<.001	3	7
CCRCC	FKBP10 →	+0.461	+0.078	<.001	<.001	3	7
UCEC	FKBP7 →	+0.502	+0.116	<.001	<.001	3	7
UCEC	MRC2 →	+0.680	+0.155	<.001	<.001	2	8
GBM	ITGA5 →	+0.480	+0.082	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060354 vs C1S — BRCA

Explore this scatter interactively →