Negative regulation of cell adhesion molecule production

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell adhesion molecule production pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCAF1_S929, WIPF1_S343, and SLC44A1_S644, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell adhesion molecule production activity versus SCAF1_S929 in OV (Pearson r = 0.91).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SCAF1_S929 →	+1.089	+0.280	<.001	<.001	3	3
UCEC	WIPF1_S343 →	+0.842	+1.912	.001	<.001	3	3
OV	SLC44A1_S644 →	-2.454	-0.060	<.001	<.001	3	3
OV	MAP4_S1151 →	-1.549	-0.121	<.001	<.001	3	3
OV	ARCN1_S220 →	-1.112	-0.198	<.001	<.001	3	3
BRCA	RETREG2_S337 →	+0.991	+0.090	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060354 vs SCAF1_S929 — OV

Explore this scatter interactively →