Negative regulation of cell adhesion molecule production

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell adhesion molecule production pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOTCH4, NOTCH1, and APOA1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOTCH4 grouped by Negative regulation of cell adhesion molecule production-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NOTCH4 →	-0.456	-2.021	.002	<.001	3	13
LUNG_SCLC	NOTCH1 →	-0.223	-1.209	<.001	<.001	3	9
LUNG_NSCLC_LUAD	APOA1 →	-0.206	-1.242	<.001	<.001	3	8
SOFT_TISSUE	MYOCD →	-0.276	-1.292	.006	.008	3	7
LARGE_INTESTINE	CXCL8 →	-0.180	-1.456	.003	<.001	3	7
LUNG_NSCLC_LUAD	NME6 →	-0.188	-0.809	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOTCH4 by Negative regulation of cell adhesion molecule production activity — LIVER

Explore this box plot interactively →