Negative regulation of cell adhesion molecule production

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell adhesion molecule production pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF25, ZNF706, and DYNC2I2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF25 grouped by Negative regulation of cell adhesion molecule production-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RNF25 →	+0.866	+1.867	.003	.001	3	5
OESOPHAGUS	ZNF706 →	+0.916	+1.148	.003	.001	3	5
UPPER_AERODIGESTIVE_TRACT	DYNC2I2 →	+1.750	+1.507	.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	SLC47A1 →	+1.017	+1.077	.005	.007	3	5
PANCREAS	NPIPB3 →	+1.293	+1.387	.007	.002	3	4
PANCREAS	NPIPB4 →	+1.485	+1.386	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF25 by Negative regulation of cell adhesion molecule production activity — URINARY_TRACT

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