Negative regulation of cell adhesion molecule production

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell adhesion molecule production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YPEL1, SOX10, and ABHD4, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell adhesion molecule production activity versus YPEL1 in SKIN (Pearson r = 1.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	YPEL1 →	+0.865	+1.155	.001	.002	1	1
SKIN	SOX10 →	+0.509	+1.155	.009	.002	1	1
SKIN	ABHD4 →	+1.150	+1.155	.009	.002	1	1
SKIN	ITPK1 →	+2.000	+1.155	<.001	.002	1	1
SKIN	TRPC4AP →	+0.205	+1.155	.002	.002	1	1
SKIN	ARFRP1 →	-0.349	-1.155	.008	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060354 vs YPEL1 — SKIN

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