Cartilage development involved in endochondral bone morphogenesis

Across TCGA cell cohorts, RNA activity of the Cartilage development involved in endochondral bone morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDAC1, FLRT2, and YWHAEP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HDAC1 grouped by Cartilage development involved in endochondral bone morphogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HDAC1 →	+0.171	+1.808	.001	<.001	3	3
PANCREAS	FLRT2 →	+0.180	+1.912	.001	<.001	3	3
OESOPHAGUS	YWHAEP1 →	+0.185	+1.808	.005	<.001	3	3
OESOPHAGUS	DECR2 →	+0.201	+1.808	.004	<.001	3	3
BREAST	OR3A1 →	+0.232	+0.838	.002	.007	2	4
BREAST	TBP →	+0.144	+0.893	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HDAC1 by Cartilage development involved in endochondral bone morphogenesis activity — OESOPHAGUS

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