Trabecula formation

Across TCGA patient cohorts, RNA activity of the Trabecula formation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2, EHD2, and SFRP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trabecula formation activity versus SYNPO2 in COAD (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SYNPO2 →	+0.599	+0.022	.004	.004	3	9
BRCA	EHD2 →	+0.663	+0.032	<.001	<.001	3	9
LSCC	SFRP1 →	+0.874	+0.055	<.001	<.001	3	8
COAD	TNS1 →	+0.472	+0.024	.001	.001	3	8
CCRCC	TNS2 →	+0.394	+0.100	<.001	<.001	3	8
BRCA	BGN →	+0.675	+0.029	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060343 vs SYNPO2 — COAD

Explore this scatter interactively →