Regulation of response to type II interferon

Across TCGA patient cohorts, RNA activity of the Regulation of response to type II interferon pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RENBP, SAMHD1, and SAMSN1_S107, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to type II interferon activity versus RENBP in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RENBP →	+0.559	+0.084	<.001	.006	3	9
UCEC	SAMHD1 →	+0.436	+0.092	.002	<.001	3	9
CCRCC	SAMSN1_S107 →	+0.631	+0.058	.001	.009	3	9
CCRCC	SASH3 →	+0.445	+0.070	<.001	<.001	3	9
BRCA	TRIM21 →	+0.400	+0.065	<.001	<.001	3	9
GBM	WAS →	+0.521	+0.081	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060330 vs RENBP — UCEC

Explore this scatter interactively →