Regulation of response to type II interferon

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of response to type II interferon pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Regulation of response to type II interferon pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and BRCA, show the opposite pattern, with higher activity associated with better survival.

SKCM, UVM, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.402	0.276	<.001	109	view →
UVM	OS	Median	All	0.366	0.755	<.001	69	view →
BRCA	OS	Quartile	All	0.639	0.539	.001	59	view →
LGG	DFS	Median	All	0.290	0.461	<.001	53	view →
THYM	DFS	Median	II,III,IV	0.640	0.919	.003	46	view →
BLCA	OS	Tertile	All	0.770	0.634	.003	41	view →
ACC	OS	Median	IV	0.244	0.842	.001	36	view →
COAD	DFS	Median	III,IV	0.568	0.289	.005	29	view →
LUSC	OS	Median	IV	0.057	0.786	.008	28	view →
KIRC	DFS	Median	IV	0.209	0.484	.002	28	view →
HNSC	OS	Quartile	IV	0.522	0.232	.007	16	view →
PRAD	DFS	Tertile	All	0.898	0.957	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0060330–SKCM (OS)

Open the SKCM breakdown →