Regulation of response to type II interferon

Across TCGA patient cohorts, RNA activity of the Regulation of response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS7BP, SYTL2, and CST2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to type II interferon activity versus RGS7BP in UCEC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RGS7BP →	-1.053	-0.655	.001	.006	3	4
BRCA	SYTL2 →	-1.070	-0.561	.007	.008	3	4
LUAD	CST2 →	-1.205	-0.357	<.001	.003	3	4
LUAD	CDCA8 →	+0.749	+0.339	.001	.002	3	4
LSCC	KIF2C →	+0.643	+0.193	<.001	.006	3	4
LSCC	LINC02769 →	-0.495	-0.292	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060330 vs RGS7BP — UCEC

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