Regulation of response to type II interferon

Across TCGA cell cohorts, RNA activity of the Regulation of response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAPK2, BCAS1, and EXOC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DAPK2 grouped by Regulation of response to type II interferon-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DAPK2 →	+0.994	+0.374	.003	.004	2	5
BREAST	BCAS1 →	+2.998	+0.329	<.001	<.001	3	4
BREAST	EXOC6 →	+0.792	+0.205	.001	.004	3	4
BREAST	AK5 →	-1.463	-0.333	<.001	<.001	3	4
PANCREAS	PRKAA2 →	+1.456	+0.341	.005	.001	3	3
BREAST	ABHD1 →	+0.697	+0.264	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DAPK2 by Regulation of response to type II interferon activity — LUNG_SCLC

Explore this box plot interactively →